Protein name:
Bile salt export pump ;
Alternative:
ATP-binding cassette sub-family B member 11 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with HAX1.
Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MSDSVILRSI | KKFGEENDGF | ESDKSYNNDK | KSRLQDEKKG | DGVRVGFFQL |
100:
FRFSSSTDIW | LMFVGSLCAF | LHGIAQPGVL | LIFGTMTDVF | IDYDVELQEL |
150:
QIPGKACVNN | TIVWTNSSLN | QNMTNGTRCG | LLNIESEMIK | FASYYAGIAV |
200:
AVLITGYIQI | CFWVIAAARQ | IQKMRKFYFR | RIMRMEIGWF | DCNSVGELNT |
250:
RFSDDINKIN | DAIADQMALF | IQRMTSTICG | FLLGFFRGWK | LTLVIISVSP |
300:
LIGIGAATIG | LSVSKFTDYE | LKAYAKAGVV | ADEVISSMRT | VAAFGGEKRE |
350:
VERYEKNLVF | AQRWGIRKGI | VMGFFTGFVW | CLIFLCYALA | FWYGSTLVLD |
400:
EGEYTPGTLV | QIFLSVIVGA | LNLGNASPCL | EAFATGRAAA | TSIFETIDRK |
450:
PIIDCMSEDG | YKLDRIKGEI | EFHNVTFHYP | SRPEVKILND | LNMVIKPGEM |
500:
TALVGPSGAG | KSTALQLIQR | FYDPCEGMVT | VDGHDIRSLN | IQWLRDQIGI |
550:
VEQEPVLFST | TIAENIRYGR | EDATMEDIVQ | AAKEANAYNF | IMDLPQQFDT |
600:
LVGEGGGQMS | GGQKQRVAIA | RALIRNPKIL | LLDMATSALD | NESEAMVQEV |
650:
LSKIQHGHTI | ISVAHRLSTV | RAADTIIGFE | HGTAVERGTH | EELLERKGVY |
700:
FTLVTLQSQG | NQALNEEDIK | DATEDDMLAR | TFSRGSYQDS | LRASIRQRSK |
750:
SQLSYLVHEP | PLAVVDHKST | YEEDRKDKDI | PVQEEVEPAP | VRRILKFSAP |
800:
EWPYMLVGSV | GAAVNGTVTP | LYAFLFSQIL | GTFSIPDKEE | QRSQINGVCL |
850:
LFVAMGCVSL | FTQFLQGYAF | AKSGELLTKR | LRKFGFRAML | GQDIAWFDDL |
900:
RNSPGALTTR | LATDASQVQG | AAGSQIGMIV | NSFTNVTVAM | IIAFSFSWKL |
950:
SLVILCFFPF | LALSGATQTR | MLTGFASRDK | QALEMVGQIT | NEALSNIRTV |
1000:
AGIGKERRFI | EALETELEKP | FKTAIQKANI | YGFCFAFAQC | IMFIANSASY |
1050:
RYGGYLISNE | GLHFSYVFRV | ISAVVLSATA | LGRAFSYTPS | YAKAKISAAR |
1100:
FFQLLDRQPP | ISVYNTAGEK | WDNFQGKIDF | VDCKFTYPSR | PDSQVLNGLS |
1150:
VSISPGQTLA | FVGSSGCGKS | TSIQLLERFY | DPDQGKVMID | GHDSKKVNVQ |
1200:
FLRSNIGIVS | QEPVLFACSI | MDNIKYGDNT | KEIPMERVIA | AAKQAQLHDF |
1250:
VMSLPEKYET | NVGSQGSQLS | RGEKQRIAIA | RAIVRDPKIL | LLDEATSALD |
1300:
TESEKTVQVA | LDKAREGRTC | IVIAHRLSTI | QNADIIAVMA | QGVVIEKGTH |
1321:
EELMAQKGAY | YKLVTTGSPI | S
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Rabbit
ELISA Kit for Human Bile salt export pump
ELISA Kit for Human Bile salt export pump
ELISA Kit for Human Bile salt export pump
ELISA Kit for Human Bile salt export pump
CLIA Kit for Human Bile salt export pump
CLIA Kit for Human Bile salt export pump
CLIA Kit for Human Bile salt export pump
CLIA Kit for Human Bile salt export pump
Polyclonal Antibody for Human Bile salt export pump
Polyclonal Antibody for Human Bile salt export pump
Polyclonal Antibody for Human Bile salt export pump
Polyclonal Antibody for Human Bile salt export pump
Monoclonal Antibody for Human Bile salt export pump
Monoclonal Antibody for Human Bile salt export pump
Monoclonal Antibody for Human Bile salt export pump
Monoclonal Antibody for Human Bile salt export pump
Protein for Human Bile salt export pump
Protein for Human Bile salt export pump
Protein for Human Bile salt export pump
Protein for Human Bile salt export pump
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis."
Strautnieks S.S.
,
Bull L.N.
,
Knisely A.S.
,
Kocoshis S.A.
,
Dahl N.
,
Arnell H.
,
Sokal E.M.
,
Dahan K.
,
Childs S.
,
Ling V.
,
Tanner M.S.
,
Kagalwalla A.F.
,
Nemeth A.
,
Pawlowska J.
,
Baker A.
,
Mieli-Vergani G.
,
Freimer N.B.
,
Gardiner R.M.
,
Thompson R.J.
more...
Nat. Genet.20:233-238(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANTS PFIC2 GLY-297; GLU-461; GLY-482; ARG-982; CYS-1153 AND GLN-1268
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANT ALA-444
3.
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W.
,
Graves T.A.
,
Fulton R.S.
,
Fulton L.A.
,
Pepin K.H.
,
Minx P.
,
Wagner-McPherson C.
,
Layman D.
,
Wylie K.
,
Sekhon M.
,
Becker M.C.
,
Fewell G.A.
,
Delehaunty K.D.
,
Miner T.L.
,
Nash W.E.
,
Kremitzki C.
,
Oddy L.
,
Du H.
,
Sun H.
,
Bradshaw-Cordum H.
,
Ali J.
,
Carter J.
,
Cordes M.
,
Harris A.
,
Isak A.
,
van Brunt A.
,
Nguyen C.
,
Du F.
,
Courtney L.
,
Kalicki J.
,
Ozersky P.
,
Abbott S.
,
Armstrong J.
,
Belter E.A.
,
Caruso L.
,
Cedroni M.
,
Cotton M.
,
Davidson T.
,
Desai A.
,
Elliott G.
,
Erb T.
,
Fronick C.
,
Gaige T.
,
Haakenson W.
,
Haglund K.
,
Holmes A.
,
Harkins R.
,
Kim K.
,
Kruchowski S.S.
,
Strong C.M.
,
Grewal N.
,
Goyea E.
,
Hou S.
,
Levy A.
,
Martinka S.
,
Mead K.
,
McLellan M.D.
,
Meyer R.
,
Randall-Maher J.
,
Tomlinson C.
,
Dauphin-Kohlberg S.
,
Kozlowicz-Reilly A.
,
Shah N.
,
Swearengen-Shahid S.
,
Snider J.
,
Strong J.T.
,
Thompson J.
,
Yoakum M.
,
Leonard S.
,
Pearman C.
,
Trani L.
,
Radionenko M.
,
Waligorski J.E.
,
Wang C.
,
Rock S.M.
,
Tin-Wollam A.-M.
,
Maupin R.
,
Latreille P.
,
Wendl M.C.
,
Yang S.-P.
,
Pohl C.
,
Wallis J.W.
,
Spieth J.
,
Bieri T.A.
,
Berkowicz N.
,
Nelson J.O.
,
Osborne J.
,
Ding L.
,
Meyer R.
,
Sabo A.
,
Shotland Y.
,
Sinha P.
,
Wohldmann P.E.
,
Cook L.L.
,
Hickenbotham M.T.
,
Eldred J.
,
Williams D.
,
Jones T.A.
,
She X.
,
Ciccarelli F.D.
,
Izaurralde E.
,
Taylor J.
,
Schmutz J.
,
Myers R.M.
,
Cox D.R.
,
Huang X.
,
McPherson J.D.
,
Mardis E.R.
,
Clifton S.W.
,
Warren W.C.
,
Chinwalla A.T.
,
Eddy S.R.
,
Marra M.A.
,
Ovcharenko I.
,
Furey T.S.
,
Miller W.
,
Eichler E.E.
,
Bork P.
,
Suyama M.
,
Torrents D.
,
Waterston R.H.
,
Wilson R.K.
more...
Nature434:724-731(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT ASN-109; ASN-116; ASN-122 AND ASN-125
5.
"Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis."
Jansen P.L.M.
,
Strautnieks S.S.
,
Jacquemin E.
,
Hadchouel M.
,
Sokal E.M.
,
Hooiveld G.J.E.J.
,
Koning J.H.
,
De Jager-Krikken A.
,
Kuipers F.
,
Stellaard F.
,
Bijleveld C.M.
,
Gouw A.
,
Van Goor H.
,
Thompson R.J.
,
Muller M.
Gastroenterology117:1370-1379(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PFIC2 VAL-238 AND SER-336
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ALA-444
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PFIC2 LEU-284 AND ASP-1004
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS BRIC2 GLY-186; GLY-297; THR-570; PRO-923; PRO-926; CYS-1050 AND HIS-1128
9.
"Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy."
Pauli-Magnus C.
,
Lang T.
,
Meier Y.
,
Zodan-Marin T.
,
Jung D.
,
Breymann C.
,
Zimmermann R.
,
Kenngott S.
,
Beuers U.
,
Reichel C.
,
Kerb R.
,
Penger A.
,
Meier P.J.
,
Kullak-Ublick G.A.
Pharmacogenetics14:91-102(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS GLN-415; ALA-444; SER-591 AND VAL-677
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS BRIC2 GLY-297 AND THR-432;CHARACTERIZATION OF VARIANTS BRIC2 GLY-297 AND THR-432
11.
"Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11)."
Lang T.
,
Haberl M.
,
Jung D.
,
Drescher A.
,
Schlagenhaufer R.
,
Keil A.
,
Mornhinweg E.
,
Stieger B.
,
Kullak-Ublick G.A.
,
Kerb R.
Drug Metab. Dispos.34:1582-1599(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS VAL-206; ALA-284; LYS-299; ALA-444; GLY-616; ALA-619; VAL-677; HIS-698; VAL-865 AND GLN-958
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ALA-444 AND VAL-677
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ALA-284; ALA-444; TYR-676; VAL-677; HIS-698 AND ARG-855;BIOPHYSICOCHEMICAL PROPERTIES;CHARACTERIZATION OF VARIANTS ALA-444; TYR-676; VAL-677 AND ARG-855